Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer’s disease: a cross-sectional study

The study, published in the Lancet Neurology,and led Led by Beau Ances, A. Boerwinkle et al. compared amyloid burden (amyloid PET) between individuals with Down syndrome and those with autosomal Alzheimer’s disease.  The study reported that individuals with Down syndrome and carriers of autosomal dominant Alzheimer’s disease mutations displayed similar amyloid deposition. Early amyloid accumulation occurred in cortical and striatal regions for both groups. However, amyloid deposition occurred earlier in individuals with autosomal dominant Alzheimer’s disease than in Down syndrome. Although mutation carriers displayed significant amyloid deposition in the medial occipital lobe, this was not observed in Down syndrome.

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