The T21RS Committee for Science & Society regularly addresses issues raised by parents and Down syndrome associations through summarizing the state-of-the-art knowledge from a scientific perspective. The Committee works together with leading scientists and clinicians (T21RS members) and is strongly committed to introducing scientific research and explaining recent findings in an understandable way through their T21RS Science & Society Bulletins. T21RS members are kindly invited to submit a T21RS Science & Society Bulletin to the Committee for publication on the T21RS website. The Committee intends to publish a Bulletin several times per year.


For authors

T21RS members are kindly invited to submit a T21RS Science & Society Bulletin to the Committee for publication on the T21RS website.

You can directly contact the chairs of the Committee for Science & Society, Dr. Anne- Sophie Rebillat (annesophie.rebillat@institutlejeune.org) or Dr. María Carmona-Iragui (mcarmonai@santpau.cat).

We are looking for new ideas/themes and proposals for bulletins.

Thank you very much!

List of bulletins


  1. S&S Bulletin 2021 (1): Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome by:Alexandra Botté 1, Jeanne Lainé 1,2, Laura Xicota1, Xavier Heiligenstein3,10, Gaëlle Fontaine1, Amal Kasri1, Isabelle Rivals4, Pollyanna Goh 5 , Orestis Faklaris 6, Jack-Christophe Cossec 1, Etienne Morel7, AnneSophie Rebillat8, Dean Nizetic5,9, Graça Raposo10 and Marie-Claude Potier1*


  1. S&S Bulletin 2019 (1): Relationship between Apgar scores and long-term cognitive outcomes in individuals with Down syndrome. by Laura del Hoyo Soriano, Tracie Rosser, Debra Hamilton, Leonard Abbeduto and Stephanie Sherman
  2. S&S Bulletin 2019 (2): A Quest for the genes: Down syndrome and Alzheimer disease. A summary of the article by Frances Wiseman, Laura J. Pulford, Victor L. J. Tybulewicz, Elizabeth M.C. Fisher by Claudia Cannavo*
  3. S&S Bulletin 2019 (3): Identifying Alzheimer’s disease in Down syndrome with NGF metabolism: hope for better treatment and diagnosis? Rowan Pentz* 1 , M. Florencia Iulita2,3, Juan Fortea, A2 . Claudio Cuello1,3,4
  4. S&S Bulletin 2019 (4): Exploring the role of astroglia in Down syndrome Álvaro Fernández0, Eduardo Domínguez0 and Mara Dierssen*


  1. S&S Bulletin 2018 (1): Summary PhD Thesis Alzheimer’s Disease & Down Syndrome
    by Florencia Iulita, T21RS Thesis Award Winner
  2. S&S Bulletin 2018 (2): Summary PhD Thesis ‘Is it possible to rescue maturation of nerve cells in Down syndrome with early pharmacological treatment?’ by Fiorenza Stagni, T21RS Thesis Award Winner
  3. S&S Bulletin 2018 (3): ‘Prof. Marie-Odile Rethoré: Her patients and research – a life’ A summary of the honourable T21RS member Prof. Rethoré by Aime Ravel, Clotilde Mircher, Daniel Satgé and Catherine Lemonnier
  4. S&S Bulletin 2018 (4): ‘What are you proud of? Everything’ A summary of World Down Syndrome day 2018 by The LonDownS Consortium, by Claudia Cannavo


  1. S&S Introduction
  2. S&S Bulletin (1): Depression in Down syndrome – a big problem?
  3. S&S Bulletin (2): Alzheimer’s disease in adults with Down syndrome – a challenge
  4. S&S Bulletin (3): Pain experience in adults with Down syndrome
  5. S&S Bulletin (4): The challenge of discovering preventive therapies for intellectual disability in Down syndrome – could there be a breakthrough?

For Down syndrome associations

The bulletins are written in easy English and are freely available for all associations or foundations that agree upon the following:

  • Mutual presentation of logos: displaying the T21RS logo (+link) on the association’s website, and T21RS will put your logo (+link) on the Science & Society section. Please send us your link and logo in PNG format.
  • You can use the Bulletin for your website, newsletters and/or paper magazines, as long as you acknowledge authorship, T21RS and the T21RS Committee for Science & Society.
  • You do not change the content of the T21RS Science & Society Bulletin.
  • You can translate the T21RS Science & Society Bulletin to your local language, however, without changing the meaning of the text.