Postdoctoral Researcher in Brandebura lab at University of Virginia, USA
The Brandebura lab is seeking a Postdoctoral Researcher/Research Associate to support our NIH funded research program investigating astrocyte dysfunction in Down Syndrome and Alzheimer’s Disease. Specifically we will be focusing on: 1.) Defining molecular changes that occur within reactive astrocytes in Down Syndrome and Alzheimer’s Disease, 2.) Targeting astrocytes to improve neuronal synaptic dysfunction, 3.) Understanding reactive astrocyte-microglia and astrocyte-vascular crosstalk in disorders of the nervous system. Required skills include animal handling, experience in confocal imaging and immunohistochemistry, and experience in wet lab techniques such as western blotting, RNA extraction, and molecular cloning. Desired skills include experience with proteomics and familiarity with bioinformatic analysis pipelines, as well as exposure to iPSC differentiation into neuronal and glial cells. The Brandebura lab is located within the Department of Neuroscience/Center for Brain Immunology and Glia (BIG Center) at Univ Virginia.
Postdoctoral employment is temporary and is normally limited to an individual who has been awarded a Ph.D. or equivalent doctorate within the previous five years and who will be involved in full-time research or scholarship at the University. Employment as a Postdoctoral Research Associate is viewed as training and is preparatory for a full-time academic or research career, is supervised by a senior scholar, and allows the appointee to publish the results of his/her research or scholarship during the training period.
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Postdoctoral Research Assistant positionat theBlizard Institute, Queen Mary University of London, UK
The Nizetic lab is leading internationally in the establishment of cellular models of neurodevelopment, ageing and neurodegeneration, and their correction using small chemicals. The postholder will lead part of a project using hiPSC systems and cerebral organoids to substantially improve our understanding of the pathomechanisms of Down syndrome and Alzheimer’s dementia, and/or the design of hi-throughput chemical screening assays for phenotype correction. They will be taught the skills of generating cerebral organoids and 3D neuronal cultures and have access to additional hiPSC from patients clinically stratified for Alzheimer’s dementia and a range of genetic models of Alzheimer’s dementia.
We are looking for an ambitious and motivated candidate with a track record of accomplishment (either during the PhD studentship, or during a previous postdoctoral research) demonstrating ability in the field of cell/molecular biology. Experience with cell culture, characterization of cell phenotypes, or work with human embryonic stem cells or iPSC would be desirable, but proven skills in transcriptome and protein structure data mining/analysis would also be advantageous.
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