T21RS Committee for Preclinical research: Yann Hérault (Institut de Génétique et de Biologie Moléculaire et Cellulaire, FR)(Chair), William Mobley (University of California-San Diego, USA), Elizabeth Fisher (University College London, UK), Marie-Claude Potier (ICM, FR), Stylianos Antonarakis (University of Geneva, CH), Jean-Maurice Delabar (CNRS, FR), Eugene Yu (Roswell Park Cancer Institute, USA), Katheleen Gardiner (University of Colorado, USA), Mara Dierssen (Centre for Genomic Regulation (CRG), SP), Anita Bhattacharyya (University of Wisconsin, USA), Randall Roper ((Indiana University-Purdue University Indianapolis, USA)
MOUSE MASTER CLASS
- 09:00 – 09:15 Registration / coffee
- 09:15 – 09:45 Overview of currently available preclinical mouse models. Yann Hérault (Institut de Génétique et de Biologie Moléculaire et Cellulaire, FR)
- 09:45 – 10:15 Genetic quality control, maintenance and breeding procedures. Eugene Yu (Roswell Park Cancer Institute, USA)
- 10:15 – 10:45 Classical behavioral phenotyping. Mara Dierssen (Centre for Genomic Regulation (CRG), SP)
- 10:45 – 11:00 Break
- 11:00 – 11:30 Craniofacial and skeletal phenotyping. Randall Roper (Indiana University-Purdue University Indianapolis, USA)
- 11:30 – 12:00 Electrophysiology. William Mobley (Univers ityof California-San Diego, USA)
- 12:00 – 12:30 Preclinical testing. Jean-Maurice Delabar (CNRS, FR)
- 12:30 – 13:00 Discussion on key information about models and their availability (moderated by Lizzy Fisher) and perspective on new animal models for Down syndrome research. Roger Reeves (Johns Hopkins University School of Medicine, USA) and Victor Tybulewicz (Francis Crick Institute, UK)